Registration Dossier
Registration Dossier
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EC number: 203-897-9 | CAS number: 111-70-6
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
An experimental study was conducted in accordance with the OECD 117 Testing Guideline (HPLC method). The objective of this study was to determine the Partition Coefficient of the test item n-heptanol. The 3 replicate determinations show that the mean log Pow value is 2.2.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.2
- at the temperature of:
- 20 °C
Additional information
The objective of the key study was to determine the Partition Coefficient of the test item n-heptanol applying the procedure described in the OECD Guideline 117 Partition Coefficient (n-octanol/water), HPLC Method. The 3 replicate determinations (see table below) show that the mean log Pow value is 2.2.
Partition Coefficient | Log Pow |
Test 1 | 2.2 |
Test 2 | 2.2 |
Test 3 | 2.2 |
Mean Value | 2.2 |
Based on this result, it can be concluded that n-heptanol is characterized by a low potential of bioaccumulation and adsorption.
The objectives of the supporting study by Veith (1979), whose results are quoted in the publication by Broderius & Kahl (1985) were to demonstrate the relationship of log P and the high-pressure liquid chromatography (HPLC) reverse-phase retention time using a wide variety of industrial chemicals, and to develop a method for estimating log P by using HPLC. The partition coefficient of heptan-1-ol was evaluated in this study performed according to a protocol similar to OECD testing guideline 117. The partition coefficient of heptan-1-ol was estimated at 2.49. This result comes to reinforce the fact that heptan-1-ol is characterized by a low potential of bioaccumulation and adsorption.
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