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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from secondary source

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: SHW000
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials): " Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.: , 1972, 21.
Reference Type:
other: Data is from authoritative database
Title:
Acute oral toxicity study of test chemical in rat
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database ), 2018
Reference Type:
other: Data is from authoritative database
Title:
Acute oral toxicity in rat
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
GESTIS Substance Database, 2018
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study in Rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
To perform Acute oral toxicity test of test chemical on rats.
GLP compliance:
not specified
Test type:
other: Not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium iodide
EC Number:
231-679-3
EC Name:
Sodium iodide
Cas Number:
7681-82-5
Molecular formula:
INa
IUPAC Name:
sodium iodide
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): sodium iodide
- Substance type: Inorganic
- Physical state: Solid
- Formula: INa
- Molecular Weight: 149.89 g/mol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Not specified
Doses:
4340 mg/kg bw
No. of animals per sex per dose:
Not specified
Control animals:
not specified
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Preliminary study:
Not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 340 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value
Mortality:
Lethal dose, 50 percent kill
Clinical signs:
other: Not specified
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 value was considered to be 4340 mg/kg bw, when rats were treated with the given test chemical orally.
Executive summary:

Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 4340 mg/kg bw. All animals were maintained under close observation for recording toxic signs and time of death . Therefore, LD50 value was considered to be 4340 mg/kg bw, when rats were treated with test chemical via oral route.