Registration Dossier
Registration Dossier
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EC number: 230-638-7 | CAS number: 7237-83-4
Endpoint summary
Administrative data
Description of key information
An acute oral toxicity study was performed in five male and five female animals. The animals were treated with tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate at 2000 mg/kg. The oral LD50 in rats was found to be greater than 2000 mg/kg.
An acute dermal toxicity study was performed in five male and five female animals. The animals were treated with tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate at 2000 mg/kg. The dermal LD50 in rats was found to be greater than 2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
One acute oral toxicity study in rats and one acute dermal toxicity study in rats were performed with tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate. Both studies showed in male and female animals an LD50 greater than 2000 mg/kg.
Justification for classification or non-classification
- oral toxicity:
Based on the above stated assessment of the acute oral toxicity of tris(oxyranymethyl)benzene-1,2,4 -tricarboxylate the substance does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
- dermal toxicity:
Based on the above stated assessment of the acute dermal toxicity of tris(oxyranylmethyl)benzene-1,2,4 -tricarboxylate (absence of toxicity up to 2000 mg/kg) the substance does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
- inhalation toxicity:
Due to the very low vapour pressure of the substance, the fact that the substance is imported into the EU in a formulated form as a granulate, the inhalation route of exposure is considered to be unlikely. Therefore no classification for acute inhalation toxicity is deemed necessary according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according CLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
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