Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-820-1 | CAS number: 127-06-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The reliability assessment of the publication is based on the fact that is peer-reviewed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acetoxime is metabolised by human and rodent hepatic cytochrome P450 enzymes to the genotoxicant and carcinogen propane 2-nitronate
- Author:
- Kohl et al
- Year:
- 1 992
- Bibliographic source:
- Carcinogenesis, 1397), 1091-1094
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The substance was incubated with liver microsomes from rats, mice and humans. The mice had been pre-treated with one of ten different inducing agents. The incubates were then subject to HPLC analysis.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetone oxime
- EC Number:
- 204-820-1
- EC Name:
- Acetone oxime
- Cas Number:
- 127-06-0
- Molecular formula:
- C3H7NO
- IUPAC Name:
- acetone oxime
Constituent 1
- Radiolabelling:
- no
Administration / exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20mM
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Propane 2-nitronate was identified as metabolite
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Propane 2-nitronate
Applicant's summary and conclusion
- Conclusions:
- Acetone oxime is metabolised in vitro by rodent and human liver microsomes to form propane 2-nitronate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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