Registration Dossier
Registration Dossier
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EC number: 203-057-1 | CAS number: 102-81-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles (limited informations).
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List V
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC
- Year:
- 1 954
- Bibliographic source:
- Arch. Ind. Hyg. Occupational Med. 10, 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (occlusive dressing, no details on weight development, clinical signs, mortality)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2-dibutylaminoethanol
- EC Number:
- 203-057-1
- EC Name:
- 2-dibutylaminoethanol
- Cas Number:
- 102-81-8
- Molecular formula:
- C10H23NO
- IUPAC Name:
- 2-(dibutylamino)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Dibutylaminoethanol
No further data available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg
No further information.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- % coverage: about 1/10 of the body surface
- Type of wrap if used: Impervious plastic film (Cuff method of Draize).
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not more than 20 ml/kg bw. - Duration of exposure:
- 24 hours
- Doses:
- No data.
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 680 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 200 - 2 360
- Mortality:
- No data.
- Clinical signs:
- other: No data.
- Gross pathology:
- No data.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
