Registration Dossier
Registration Dossier
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EC number: 203-479-6 | CAS number: 107-29-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1974
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Not GLP and not according to international test guideline. No detailed information about the protocol present. Nevertheless,
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to the criteria specified in Paragraph 191.1 (e) (2) and (f) (2) of the Final Order, Enforcement Regulations, Federal Register, Vol. 26, No. 155, p. 7336, 12 August, 1961
- GLP compliance:
- no
- Remarks:
- Study from 1974
- Limit test:
- yes
Test material
- Reference substance name:
- Acetaldehyde oxime
- EC Number:
- 203-479-6
- EC Name:
- Acetaldehyde oxime
- Cas Number:
- 107-29-9
- Molecular formula:
- C2H5NO
- IUPAC Name:
- acetaldehyde oxime
- Details on test material:
- - Test material: 50% AAO
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Average weight: 290 g
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 72 L
- Air flow: 10 L/min
- System of generating particulates/aerosols: a modified nebulizer and a manually operated syringe - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- Nominal concentration: 5.7 mg/L air (on a weight basis, i.e. weights of material and air, the concentration was over 5000 ppm)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 5.7 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: LC0 for 50% solution of AAO in water.
- Other findings:
- Animals did not appear stressed during exposure.
Applicant's summary and conclusion
- Conclusions:
- No mortalities observed at a nominal concentration of 5.7 mg/L air.
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