Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
The QSAR model used to achieve the study has been fully validated following the OECD recommendations (OECD, 2004a). For both constituents, the test item falls partially within the applicability domain of the model. Therefore, the predicted ACUTE TOXICITY TO DAPHNIDS (48-HOUR EC50) is considered as an “extrapolation” because the solubility of the substance is so low that it falls beyond the point at which toxicity data crosses the solubility regression line. As no toxicity can be observed beyond the solubility limit (and any effect concentrations can only be related to physical interaction which is not environmentally relevant), it is no longer possible to construct a regression line beyond the solubility limit. However, the lack of statistical fit does not indicate that the conclusion “toxicity >solubility limit” is erroneous.
No daphnid data are available in our dataset for substances with a solubility as low as that of the test items, and strictly speaking the results should be considered as an extrapolation. However, because any substance with a solubility lower than the solubility limit regression line used in this QSAR will not meet the criteria of toxicity examined in this endpoint. The endpoint can be considered as falling under the domain >solubility limit. This result should be considered as reliable with restrictions (descriptor domain, structural domain).
The ACUTE TOXICITY TO DAPHNIDS (48-HOUR EC50) of both constituents of the test item was greater than their subcooled liquid water solubility.
95% confidence interval (α = 0.05): not applicable
Additional information
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