Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 245-740-7 | CAS number: 23564-05-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March to April 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.4
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not reported
- Conclusions:
- The log Pow was found to be 1.4 at 25 °C.
- Executive summary:
A study was conducted according to OECD Guideline 107 using the Shake Flask method. The partition coefficient (Pow) of the test item between n-octanol and water was determined by different volume of solvents and twice extraction. The mean Pow was determined to 25.3. Consequently, the log Pow is 1.4 at 25 °C.
Reference
The partition coefficient (Pow) of the test item between n-octanol and water was determined by different volume of solvents and twice extraction. The partition conditions, the test item concentration and their Pow are summarized in the next table.
Volume (mL) n-octanol/water |
Sample No. |
Extraction |
Test item concentration in n-octanol (ppm) |
Test item concentration in water (ppm) |
Total test item concentration (ppm) |
Pow |
20/20 |
1 |
First |
92.66 |
3.81 |
96.47 |
24.3 |
20/20 |
2 |
First |
97.96 |
3.76 |
101.72 |
26.1 |
20/20 |
3 |
First |
95.54 |
3.88 |
99.42 |
24.6 |
20/10 |
4 |
First |
96.43 |
3.76 |
100.19 |
25.6 |
20/10 |
5 |
First |
96.44 |
3.74 |
100.18 |
25.8 |
20/10 |
6 |
First |
95.63 |
3.89 |
99.52 |
24.6 |
20/40 |
7 |
First |
94.88 |
3.59 |
98.47 |
26.4 |
20/40 |
8 |
First |
91.38 |
3.66 |
95.04 |
25.0 |
20/40 |
9 |
First |
90.94 |
3.62 |
94.56 |
25.1 |
20/20 |
10 |
Second |
89.16 |
3.55 |
92.71 |
25.1 |
20/20 |
11 |
Second |
89.28 |
3.54 |
92.82 |
25.2 |
20/20 |
12 |
Second |
87.88 |
3.43 |
91.31 |
25.6 |
|
|
|
|
|
MEAN |
25.3 |
Description of key information
The log Pow was found to be 1.4 at 25 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.4
- at the temperature of:
- 25 °C
Additional information
A study was conducted according to OECD Guideline 107 using the Shake Flask method. The partition coefficient (Pow) of the test item between n-octanol and water was determined by different volume of solvents and twice extraction. The mean Pow was determined to 25.3. Consequently, the log Pow is 1.4 at 25 °C.
Furthermore, an older study is available. In this study according to OECD Guideline 107 (1981) the octanol/water partition coefficient was determined to be 25.1 at 25 °C and pH values of 5, 6 and 7. This values corresponds to a log Pow of 1.4.
Source: Soeda, Shiotani, Thiophanate-methyl - Octanol/ water partition coefficient, 1986
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
