Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 284-557-7 | CAS number: 84929-79-3 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Styrax benzoin, Styracaceae.
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- The study was conducted before the requirement of LLNA method was mandated.
Data source
Reference
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients
- Author:
- Bickers D et al
- Year:
- 2 005
- Bibliographic source:
- Food and Chemical Toxicology 43: 799–836
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- Freund's complete adjuvant test
- Justification for non-LLNA method:
- The study was conducted before the requirement of LLNA method was mandated.
Test material
- Reference substance name:
- trans-cinnamic acid
- EC Number:
- 205-398-1
- EC Name:
- trans-cinnamic acid
- Cas Number:
- 140-10-3
- Molecular formula:
- C9H8O2
- IUPAC Name:
- (2E)-3-phenylprop-2-enoic acid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Induction
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% w/w
Challenge
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% w/w
- No. of animals per dose:
- 10
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Group:
- test chemical
- Dose level:
- 10%
- Remarks on result:
- positive indication of skin sensitisation
- Key result
- Group:
- negative control
- Dose level:
- 0%
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Group:
- positive control
- Dose level:
- 10%
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the study conditions, the test substance is considered to be weak to moderate skin sensitiser in guineapigs.
- Executive summary:
A study was conducted to determine the skin sensitisation potential according to the Modified Freund's Complete Adjuvant test method. The test substance was applied at 10% in acetone in both induction as well as challenge phases. Under the study conditions, the test substance is considered to be weak to moderate skin sensitiser in guineapigs (Bickers, 2005).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
