Reaction product of saturated palm kernel fatty acids and oxybispropanediol

Toxicity to microorganisms

Administrative data

Endpoint:

activated sludge respiration inhibition testing

Type of information:

other: Information based on a weight of evidence approach

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The end-point is based on an expert weigthhtf evidence approach based on structural analogue and hydrolysis products

Justification for type of information:

No data is available for "Reaction product of saturated palm kernel fatty acids and oxybispropanediol". The toxicokinetics of this substance is therefore assessed in a weight of evidence analysis based on existing data on similar compounds. See the attached report.

The following type of substances were included in the assessments: other glycerol esters (both data and QSAR), glycerols, fatty acids and alcohol ethoxylates. The main data sources were: NICNAS, Danish EPA QSAR, the HERA reports for alcohol ethoxylates and fatty acids.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The information is based on a weight of evidence approach.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Reaction product of saturated palm kernel fatty acids and oxybispropanediol

EC Number:

947-750-3

Molecular formula:

mainly C12 fatty acid but also containing C10, C12, C14, C16 and C18 fatty acids

IUPAC Name:

Reaction product of saturated palm kernel fatty acids and oxybispropanediol

Test material form:

other: Paste

Details on test material:

Same ID as the registered substance

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Effect concentrations 2

Key result

Duration:

3 h

Dose descriptor:

NOEC

Effect conc.:

1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Conclusions:

“Reaction product of saturated palm kernel fatty acids and oxybispropanediol” is an UVCB substance. Several test data on short-term toxicity is found on the main constituents, read-across to relevant substance group and expected primary degradation products.
The lowest effect concentration to microorganism is found for 1,2,3-Propanetriol, homopolymer, decanoate/Polygyceryl-6 Dicaprate with a 3hr-NOEC=1000 mg/L and a 3hr-IC50>1000 mg/L. This is to be used for “Reaction product of saturated palm kernel fatty acids and oxybispropanediol”.

Executive summary:

“Reaction product of saturated palm kernel fatty acids and oxybispropanediol” is an UVCB substance. Several test data on short-term toxicity is found on the main constituents, read-across to relevant substance group and expected primary degradation products.

The lowest effect concentration to microorganism is found for 1,2,3-Propanetriol, homopolymer, decanoate/Polygyceryl-6 Dicaprate with a 3hr-NOEC=1000 mg/L and a 3hr-IC50>1000 mg/L. This is to be used for “Reaction product of saturated palm kernel fatty acids and oxybispropanediol”.