Registration Dossier
Registration Dossier
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EC number: 481-830-4 | CAS number: 3687-22-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: SNIF
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 008
- Reference Type:
- other: SNIF#001-4.1.11-01
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- other: Rat, Sprague-Dawley
Administration / exposure
- Vehicle:
- other: Corn oil.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 300 mg/kg bw
- Mortality:
- Female: 50 mg/kg bw; Number of animals: 6; Number of deaths: 0
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 3 - Clinical signs:
- Signs of toxicity related to dose levels:
Dose-level of 300 mg/kg (three females)
All the animals were found dead on day 2. No clinical signs
were recorded within 4 hours of treatment.
Dose-level of 50 mg/kg (three females then confirmation on
three other females)
No deaths were recorded at this dose-level.
Hypersalivation was observed 30 minutes after treatment in
3/6 animals. Hypoactivity was observed 1 h 30 after
treatment in 1/6 animals. No other clinical signs were noted
during the study. - Gross pathology:
- Effects on organs:
At necropsy, no apparent abnormalities were observed in any
animals.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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