Registration Dossier
Registration Dossier
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EC number: 500-215-4 | CAS number: 68475-94-5
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 October 2017 to 20 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: The test system utilized a high performance liquid chromatograph and a cyanopropyl reverse phase HPLC column, containing lipophilic and polar moieties.
- Radiolabelling:
- no
- Test temperature:
- 30 ºC
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent Technologies 1100 Series, incorporating autosampler and workstation
- Type: ultraviolet (UV) for the dead time and reference standards, and evaporative light scattering detector (ELSD) for the test item
- Type, material and dimension of analytical (guard) column: Waters XSelect HSS CN 5 μm (150 x 4.6 mm id)
- Detection system: ultraviolet (UV) for the dead time and reference standards, and evaporative light scattering detector (ELSD) for the test item
The dead time was determined by measuring the retention time of formamide (purity* 99.6%, 727 mg/L solution in mobile phase).
MOBILE PHASES
- Type: methanol: water (55:45 v/v)
- Experiments with additives carried out on separate columns: yes
- pH: 5.6
- Solutes for dissolving test and reference substances: methanol
REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, α-Endosulfan, Phenanthrene, Diclofop-methyl, and DDT
REPETITIONS
- Number of determinations: duplicate
EVALUATION
- Calculation of capacity factors k': K=(Tr-T0)/T0
- Determination of the log Koc value: Log10Koc = (log10K - A)/B - Key result
- Type:
- Koc
- Value:
- > 427 000 dimensionless
- pH:
- 7
- Temp.:
- 30 °C
- Matrix:
- cyanopropyl reverse phase HPLC column, containing lipophilic and polar moieties
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10E5, log10 Koc >5.63.
Reference
Description of key information
Adsorption Coefficient. Greater than 4.27 x 105, log10Koc >5.63,determined using an HPLC screening method designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Key value for chemical safety assessment
- Koc at 20 °C:
- 427 000
Additional information
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