Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-942-6 | CAS number: 13557-75-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: Industry bulletin report
- Adequacy of study:
- supporting study
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 979
- Reference Type:
- publication
- Title:
- Actyl lactylates in cosmetics
- Author:
- Murphy LJ, Baiocchi F
- Year:
- 1 978
- Bibliographic source:
- Drug Cosmet Ind 5: 35-45
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Regulations for the Enforcement of the Federal Hazardous Substances Act
- Version / remarks:
- 17 September 1964
- Principles of method if other than guideline:
- Primary skin irritation & corrosivity in albino rabbits (evaluated in accordance with the techniques specified in the Regulations for the Enforcement of the Federal Hazardous Substances Act (Revised Federal Register September 17, 1964))
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-(1-carboxylatoethoxy)-1-methyl-2-oxoethyl laurate
- EC Number:
- 236-942-6
- EC Name:
- Sodium 2-(1-carboxylatoethoxy)-1-methyl-2-oxoethyl laurate
- Cas Number:
- 13557-75-0
- Molecular formula:
- C18H32O6.Na
- IUPAC Name:
- sodium 2-{[2-(dodecanoyloxy)propanoyl]oxy}propanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Test material name: Pationic 138C
- Final concentration: 10 % (w/w)
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Amount / concentration applied:
- 10% (w/w) concentration
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Sodium lauroyl lactylate (Pationic 138C; 10 % concentration) has been shown to have no skin irritation potential in albino rabbits.
- Executive summary:
The bulletin by Patco Cosmetic Products showed no indication of skin irritation (primary irritation index of 0) in albino rabbits for the test item sodium lauroyl lactylate (Pationic 138C; 10 % concentration). It was mentioned in the paper that the study was evaluated in accordance with the techniques specified in the Regulations for the Enforcement of the Federal Hazardous Substances Act (Revised Federal Register September 17, 1964).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
