Registration Dossier
Registration Dossier
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EC number: 934-512-9 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- From November 09, 2017 to November 27, 2017
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
- Remarks:
- The Isoteniscope method is not suitable for UVCB substances.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- isoteniscope
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 1 039.91 Pa
- Remarks on result:
- other: Average of three readings
- Conclusions:
- Under the study conditions, the vapour pressure of the test substance was determined to be 1039.91 Pa at 20°C.
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance, according to the EU Method A4, isoteniscope method, in compliance with GLP. Under the study conditions, the vapour pressure of the test substance was determined to be 1039.91 Pa at 20°C (Chilworth, 2017).
Reference
Result
|
Deionised Water (reference) |
Test substance |
Test 1 |
2320 Pa |
1106.58 Pa |
Test 2 |
2333 Pa |
999.92 Pa |
Test 3 |
2333 Pa |
999.92 Pa |
Average |
2329 Pa |
1039.91 Pa |
Description of key information
Vapour pressure of the test substance was determined using the isoteniscope method, according to OECD Guideline 104 (Chilworth, 2017) as well as using QSAR model of EPISuite v.11 (USEPA, 2018).
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Additional information
- Experimental VP: 1039.61 Pa at 20°C (isoteniscope method); the measured VP value is considered to be not reliable, as the test method used for determination is not suitable for UVCB substances;
- Weighed average QSAR based VP: 1.88E-12 Pa at 25°C; the estimates for the major constituents are considered to be reliable with restrictions, as they do not completely fall within the applicability domain.
Overall, based on the above information, the test substance can be considered to have low volatility. However, in absence of a reliable experimental study with the test substance, the QSAR based VP has been considered further for hazard/risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
