Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2019
- Justification for type of information:
- Please refer to read-across justification attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- not measured
- % Recovery:
- 92
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 102
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- 110
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- Remarks on result:
- hydrolytically stable based on preliminary test
Reference
Description of key information
Hydrolysis preliminary test was carried out with the source test item at 50 ± 0.5 °C at three different pH values. After five days the source item proved to be hydrolytically stable.
Key value for chemical safety assessment
Additional information
No data on the substance itself is available. Therefore, read-across was applied to the source substance Phosphoric acid, 2-ethylhexyl ester, sodium salt (CAS 68186-64-1). This approach is considered appropriate since both substances are UVCB substances consisting of a mono-, bis- and tris- substituted phosphate with C-chains (4 - 6 C), only the cation is different. In the target substance the cation is ammonium, while the source substance has sodium.
The hydrolysis of the source test item was assessed in accordance with the OECD guideline 111 and the EU method C.7 in a preliminary test. The hydrolysis of the source item in different aqueous buffer solutions (pH = 4, 7 and 9) at 50 °C was investigated. The test solutions were analysed at the start of the test and after five days with five replicate samples each. Two replicate tubes filled with control buffers were analysed at the start and at the end of the incubation. Aqueous and control samples were hundredfold diluted with the mobile phase and analysed by LC-MS/MS method. The recovery of the test item after 5 days at each pH value was in the range of 92 – 110 %. In the course of the preliminary test the source item proved to be hydrolytically stable at pH 4, 7 and 9.
Due to the structural similarities between the source and the target substance, the target substance is also considered to be hydrolytically stable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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