Registration Dossier
Registration Dossier
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EC number: 218-159-1 | CAS number: 2057-49-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 December 2009 to 18 February 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Translation lacks Appendix 3 outlining the details of the Acute Toxicity Test.
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Bioaccumulation Tests of Chemical Substances in Fish/Shellfish Bodies for Test Methods for New Chemical Substances, 2003, Manufacturing Industries Bureau, 2003 and Environmental Health Policy Planning Division 2006.
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- The test substance is listed as PPP or Pyridine, 4-(3-phenylpropyl) CAS # 2057-49-0.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- “Himedaka” killifish (Oryzias latipes, Adrianichthyidae) – The test organism, Oryzias latipes were bred in house. Test organisms were from an egg collection date of June 30, 2009 and were 2 ± 1 cm in length and weighted about 0.2 g.
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Test temperature:
- 24 ± 1˚C
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 5.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- An acute toxicity test of the test substance on the killifish determined a 96-h LC50 of 5.7 mg/L.
Reference
Description of key information
The key study was a carp bioaccumulation test conducted following the guideline for Bioaccumulation Tests of Chemical Substances in Fish/Shellfish Bodies for Test Methods for New Chemical Substances (Pharmaceutical and Food Safety Bureau Notice No. 1121002 dated November 21, 2003, Manufacturing Industries Bureau Notice No. 2 dated November 13, 2003, Environmental Health Policy Planning Division Notice No. 031121002, Final Amendment: November 20, 2006) and GLP standards. A preliminary acute toxicity test of the test substance on the killifish determined a 96-h LC50 of 5.7 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.7 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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