Synthetic resin, a reaction product of 4,4'-bis(N-maleimido)diphenylmethane with 3-aminobenzoic acid hydrazide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018-01-08 to 2018-02-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2014

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Key result

Water solubility:

28.3 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

7

Table 1: Solubility Results for Compimide 183 at 20 °C

Sample of the Equilibrium	Compimide 183 [mg/L]³
	at 0.4 mL/min	at 0.2 mL/min
1	29.5	26.8
2	30.0	26.7
3	30.3	26.9
4	29.8	26.6
5	30.5	25.6	Overall [mg/L]
Mean	30.0	26.5	28.3
Deviation [%]	4^1	5^1	13²
SD±	0.4	0.5

SD = Standard deviation

1) = Calculation according to formula : Deviation = n(c_max- c_min) x 100/c_min

2) = Calculation according to formula: Deviation = |(c₁ -c₂)| x 100 / c₁

3) = Mean value of two injections; for the third sample at 0.2 mL/min, one injection was eliminated as an outlier

Conclusions:

In the present test the water solubility of Compimide 183 was determined to be 28.3 mg/L (20°C, pH 7) using the Column Elution Method.

Description of key information

- study conducted according to OECD guideline 105 (1995), the water solubility of Compimide 183 was determined using the column elution mehtod, the water solubility is considered to be 28.3 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:

28.3 mg/L

at the temperature of:

20 °C