Registration Dossier
Registration Dossier
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EC number: 250-195-3 | CAS number: 30431-54-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Endpoint: Assessment of Toxicokinetic Behaviour5. Toxicokinetics 5.9 Protein-binding. OECD 417
Dependent variable: HPLC chromatographic retention index logk(HSA) (mM)
Model or submodel name: QSAR for human serum albumin binding
Model version: 03.10.2009
descriptor domain All descriptor values for bis(3,4,6-trichloro-2-pentoxycarbonylphenyl) oxalate fall in the applicability domain (training set value ±30%).
The prediction reliability in terms of classification is estimated as 82 %.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Human Serum Albumin Binding of bis(3,4,6-trichloro-2-pentoxycarbonylphenyl) oxalate. QSAR assessment.
- Year:
- 2 018
- Bibliographic source:
- QSAR for human serum albumin binding Model version: 03.10.2009
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on CSA R.6
Test material
- Reference substance name:
- Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate
- EC Number:
- 250-195-3
- EC Name:
- Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate
- Cas Number:
- 30431-54-0
- Molecular formula:
- C26H24Cl6O8
- IUPAC Name:
- pentyl 2,3,5-trichloro-6-[(2-oxo-2-{3,4,6-trichloro-2-[(pentyloxy)carbonyl]phenoxy}acetyl)oxy]benzoate
1
Results and discussion
Toxicokinetic / pharmacokinetic studies
Transfer into organs
- Transfer type:
- other: Protein-binding
- Observation:
- other: non-binding
Applicant's summary and conclusion
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