O-(ethoxycarbonyl)-N-(1-methyl-2-oxo-2-phenylethylidene)hydroxylamine

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 July 2017 to 05 October 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Atm. press.:

101 kPa

Decomposition:

yes

Decomp. temp.:

191 °C

Determination 1

- Atmospheric pressure: 100.6 kPa

- Crucible weight loss: 100 %

Table 1: Thermographic Data – Determination 1

Thermal Event	Interpretation	Onset Temperature
Endotherm	Melting	58.9 ºC (332 K)
Exotherm	Reaction/Decomposition	192 ºC (465 K)
Endotherm	Volatilisation	269 ºC (542 K)

 

Determination 2

- Atmospheric pressure: 100.6 kPa

- Crucible weight loss: 100 %

Table 2: Thermographic Data – Determination 2

Thermal Event		Interpretation		Onset Temperature
Endotherm		Melting		58.9 ºC (332 K)
Exotherm		Reaction/Decomposition		193 ºC (466 K)
Endotherm		Volatilisation		273 ºC (546 K)

 

Determination 3

- Atmospheric pressure: 101.5 kPa

- Crucible weight loss: 0 %

Table 3: Thermographic Data – Determination 3

Thermal Event	Interpretation	Onset Temperature
Endotherm	Melting	59.2 ºC (332 K)

 

Determination 4

- Atmospheric pressure: 101.5 kPa

- Crucible weight loss: 64 %

Table 4: Thermographic Data – Determination 4

Thermal Event	Interpretation	Onset Temperature
Endotherm	Melting	59.0 ºC (332 K)
Exotherm	Reaction/Decomposition	191 ºC (464 K)

 

Determination 5

- Atmospheric pressure: 101.0 kPa

- Crucible weight loss: 52 %

Table 5: Thermographic Data – Determination 5

Thermal Event	Interpretation	Onset Temperature
Endotherm	Melting	58.9 ºC (332 K)
Exotherm	Reaction/Decomposition	194 ºC (467 K)

 

Discussion

- The test material was assessed initially as an off white powder. The appearance of the residues after thermal analysis (recorded on each thermogram) and the crucibles’ weight loss confirmed decomposition of the test material with volatilisation.

- Determination of the boiling temperature was not possible, since the test material was found to react/decompose from 191 ± 0.5 °C (464 ± 0.5 K) at approximately 101 kPa.

Conclusions:

Under the conditions of this study, determination of the boiling temperature was not possible, since the test material was found to react/decompose from 191 ± 0.5 °C (464 ± 0.5 K) at approximately 101 kPa.

Executive summary:

The boiling point of the test material was investigated in accordance with the standardised guidelines OECD 103 and EU Method A.2, under GLP conditions using differential scanning calorimetry.

Aliquots of test material were placed in crucibles and were subjected to several thermal programs under an air atmosphere. During the experiments, the difference in heat flow between the sample crucible and the reference crucible (empty) was measured and recorded by the instrument.

The test material was assessed initially as an off white powder. The appearance of the residues after thermal analysis (recorded on each thermogram) and the crucibles’ weight loss confirmed decomposition of the test material with volatilisation.

Under the conditions of this study, determination of the boiling temperature was not possible, since the test material was found to react/decompose from 191 ± 0.5 °C (464 ± 0.5 K) at approximately 101 kPa.

Description of key information

Under the conditions of this study, determination of the boiling temperature was not possible, since the test material was found to react/decompose from 191 ± 0.5 °C (464 ± 0.5 K) at approximately 101 kPa.

Additional information

The boiling point of the test material was investigated in accordance with the standardised guidelines OECD 103 and EU Method A.2, under GLP conditions using differential scanning calorimetry. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Aliquots of test material were placed in crucibles and were subjected to several thermal programs under an air atmosphere. During the experiments, the difference in heat flow between the sample crucible and the reference crucible (empty) was measured and recorded by the instrument.

The test material was assessed initially as an off white powder. The appearance of the residues after thermal analysis (recorded on each thermogram) and the crucibles’ weight loss confirmed decomposition of the test material with volatilisation.

Under the conditions of this study, determination of the boiling temperature was not possible, since the test material was found to react/decompose from 191 ± 0.5 °C (464 ± 0.5 K) at approximately 101 kPa.