Registration Dossier
Registration Dossier
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EC number: 947-802-5 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- February - March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Ecotoxicity by QSAR based on the substance constituents
- Justification for type of information:
- No experimental study has been performed but reliable QSAR: please refer to Attached Justification enclosed document.
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- QSAR model adapted specifically from test guideline: OECD 202, EU C.2
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.004 mg/L
- Details on results:
- 95% confidence limits (mg test item.L-1): 0.0020 – 0.0068
- Validity criteria fulfilled:
- yes
- Remarks:
- see QRMF and QRPF
- Conclusions:
- Daphnia EC50 = 0,0037mg test item/L-1
- Executive summary:
Prediction for OECD 202 test results by Holistic HA QSAR iSaferat
model: Daphnia EC50 = 0,0037mg test item/L of benzyltetradecyldimethylammonium bromide
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- February - March 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Ecotoxicity by QSAR based on the substance constituents
- Justification for type of information:
- No experimental study has been performed but reliable QSAR: please refer to Attached Justification enclosed document
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- QSAR model adapted specifically from test guideline: OECD 202, EU C.2
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.025 mg/L
- Details on results:
- 95% confidence limits (mg test item.L-1): 0.013 – 0.045
- Validity criteria fulfilled:
- yes
- Remarks:
- see QRMF and QPRF
- Conclusions:
- Daphnia EC50= 0,025mg/L
- Executive summary:
Prediction for OECD 202 test result by Holistic HA-QSAR iSafeRat model
Daphnia EC50 = 0,025 mg/L of Benzyldodecyldimethylammonium bromide
Referenceopen allclose all
Description of key information
Prediction for OECD 202 test results by Holistic HA QSAR iSaferat model:
- Daphnia EC50 = 0,0037mg test item/L of benzyltetradecyldimethylammonium bromide
- Daphnia EC50 = 0,025 mg/L of Benzyldodecyldimethylammonium bromide
Worst case approach is chosen for classification: EC50 of 0,0037 mg/L is chosen for classification (Acute aquatic toxicity category 1 with M factor of 100).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.004 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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