2-morpholinoethanesulphonic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-03-09 from 2016-07-18

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Version / remarks:

12 May 1981

Deviations:

no

GLP compliance:

yes

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Key result

Percentile:

D10

Mean:

21.09 µm

St. dev.:

0.42

Key result

Percentile:

D50

Mean:

213.29 µm

St. dev.:

4.71

Key result

Percentile:

D90

Mean:

547.6 µm

St. dev.:

7.57

The particle size distribution was determined using the laser diffraction method with dry dispersion. The dispersing energy was adjusted to 2.5 bar, the feed rate was 30 %.

Two measurements have been performed. The following results were obtained. The L₁₀ D (v, 0.1) was determined to be 21.09 µm, the L₅₀ D (v, 0.5) was determined to be 213.29 µm and the L₉₀ D (v, 0.9) was determined to be 547.60 µm. 47.9 % of the total sample volume consisted of particles with sizes between 2 and 200 µm and 52.1 % of the sample volume consisted of particles larger than 200 µm. No particles smaller than 2 µm were observed.

99.5 % of the test item passed the 2 mm sieve in the additional sieve test. The formation of clustered particles, therefore, can be obtained as negligible for the test results.

 

Table 1. Particle Size Distribution

	Measurement 1 [µm]	Measurement 2 [µm]	Average [µm]
L10 D (v, 0.1)	21.391	20.794	21.09
L50 D (v, 0.5)	216.624	209.965	213.29
L90 D (v, 0.9)	552.955	542.245	547.60

 

Table 2. Distribution in Fractions

Fraction [µm]	Measurement 1 [%]	Measurement 2 [%]	Average [%]
Up to 2 µm	0.00	0.00	0.0
2 -200 µm	47.32	48.40	47.9
Over 200 µm	52.68	51.61	52.1

 

Conclusions:

The median mass diameter was determined as 213.29 µm, while the 10 % quantile was 21.09 µm and the 90 %-quantile was 547.60 µm.

Executive summary:

The particle size distribution was determined in an experimental study under GLP conditions according to OECD Test Guideline 110 using the laser diffraction method. The L₁₀ D (v, 0.1) was determined to be 21.09 µm, the L₅₀ D (v, 0.5) was determined to be 213.29 µm and the L₉₀ D (v, 0.9) was determined to be 547.60 µm. 47.9 % of the total sample volume consisted of particles with sizes between 2 and 200 µm and 52.1 % of the sample volume consisted of particles larger than 200 µm. No particles smaller than 2 µm were observed.

Description of key information

The median mass diameter was determined as 213.29 µm, while the 10 % quantile was 21.09 µm and the 90 %-quantile was 547.60 µm (reference 4.5-1).

Additional information

The particle size distribution was determined in an experimental study under GLP conditions according to OECD Test Guideline 110 using the laser diffraction method. The L₁₀ D (v, 0.1) was determined to be 21.09 µm, the L₅₀ D (v, 0.5) was determined to be 213.29 µm and the L₉₀ D (v, 0.9) was determined to be 547.60 µm. 47.9 % of the total sample volume consisted of particles with sizes between 2 and 200 µm and 52.1 % of the sample volume consisted of particles larger than 200 µm. No particles smaller than 2 µm were observed.