Registration Dossier
Registration Dossier
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EC number: 285-397-0 | CAS number: 85085-75-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thymus zygis, Labiatae.
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 1.087 mg/L
- Conclusions:
- LC50 of daphnia is 1.087 mg/L for carvacrol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 0.278 mg/L
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- LC50 of daphnia is 0.278 mg/L for gamma-terpinene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 0.29 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 0.29 mg/L for linalol.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.213 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 1.213 mg/L for p-cymene.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data comes from an online compilation using secondary data sources. There is no experimental study reference, however data provided from validated QSAR.
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.098 mg/L
- Validity criteria fulfilled:
- not specified
- Conclusions:
- LC50 of daphnia is 1.087 mg/L for thymol.
Referenceopen allclose all
Description of key information
Based on a weight of evidence approach, the acute toxicity of thymus zygis oil to aquatic invertebbrates (daphnia) can be estimated using adequate toxicity date of major constituents. Five constituents were considered representing more than 82.4% of the UVCB substance.These data are summarized in the table below :
| Mains consituents | CAS Number | LC50 daphnia 48h (mg/L) | Source | |
| Thymol (at 51%) | 89-83-8 | 1.087 | ECOSAR v1.11 | |
| P-cymene (at 16%) | 99-87-6 | 1.213 | ECOSAR v1.11 | |
| Gamma-terpinene (at 8.7%) | 99-85-4 | 0.278 | ECOSAR v1.11 | |
| Linalol (at 3.6%) | 78-70-6 | 0.290 | ECOSAR v1.11 | |
| Carvacrol (at 3.1%) | 499-75-2 | 1.087 | ECOSAR v1.11 |
|
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.772 mg/L
Additional information
With a LC50 daphnia value of 0.772 mg/l, the substance is classified H411 according to the table 4.1.0 b. i (as the substance is not readily biogradable) of CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
