(+)-bornan-2-one

Genetic toxicity: in vivo

Administrative data

Endpoint:

genetic toxicity in vivo

Remarks:

Type of genotoxicity: other: chromosomal damage

Type of information:

experimental study

Remarks:

the registered substance and 76-22-2 are sharing the similar chemical structure and classification, so we generate the studies of the registered substance by read-across

Adequacy of study:

key study

Study period:

1999

Reliability:

2 (reliable with restrictions)

Justification for type of information:

source substance and target substance are sharing very similar structural formula

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1999

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Food and Drug Administration (FDA) Good Laboratory Practice Regulations for Nonclinical Studies (GLP Guidelines)

GLP compliance:

yes

Type of assay:

micronucleus assay

Test material

Test material information

Constituent 1

Reference substance name:

(+)-bornan-2-one

EC Number:

207-355-2

EC Name:

(+)-bornan-2-one

Cas Number:

464-49-3

Molecular formula:

C10H16O

IUPAC Name:

1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

Test material form:

solid

Test animals

Species:

mouse

Strain:

B6C3F1

Sex:

male/female

Details on test animals or test system and environmental conditions:

The NTP also routinely conducts peripheral blood micronucleus tests on mice that are treated in the 13-week toxicity studies as part of the bioassay program

Administration / exposure

Route of administration:

other: inhalation, dosed-feed, drinking water, oral gavage, skin painting

Vehicle:

Ethanol

Duration of treatment / exposure:

90 Days

No. of animals per sex per dose:

there are normally 5 male animals per treatment group

Examinations

Statistics:

in the micronucleus test, animals are treated with a chemical and then the frequency of micronucleated cells is determined at some specified time after treatment. If a treated group of animals shows significantly higher frequencies of micronucleated cells than do the untreated control animals, then the chemical is considered to be capable of inducing structural and/or numerical chromosomal damage.

Results and discussion

Test results

Key result

Sex:

male/female

Genotoxicity:

negative

Toxicity:

no effects

Additional information on results:

After a 24-hour exposure to the camphor, no dose-group of either sex showed a significant increase in micronucle iscompared to the control.