Registration Dossier
Registration Dossier
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EC number: 212-975-1 | CAS number: 894-93-9
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Referenceopen allclose all
- Reference Type:
- other: ECOSAR calculation
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
- Reference Type:
- other: Estimation software
- Title:
- ECOlogical Structure-Activity Relationship Model (ECOSAR) Class Program v1.11
- Author:
- US EPA
- Year:
- 2 012
- Bibliographic source:
- United States Environmental Protection Agency, Washington DC, USA; March 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- ECOSAR v1.11: Estimation of acute toxicity to Dpahnid for chemical class "Schiff Bases" and "Neutral Organic SAR (Baseline Toxicity)"
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
- EC Number:
- 212-975-1
- EC Name:
- 1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
- Cas Number:
- 894-93-9
- Molecular formula:
- C17H13NO2
- IUPAC Name:
- 1-[(1E)-[(2-hydroxyphenyl)imino]methyl]naphthalen-2-ol
Constituent 1
Test organisms
- Test organisms (species):
- other: Daphnid
Study design
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.845 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: ECOSAR class: "Schiff Bases-Azomethine"; Substance within applicability domain of the model.
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 7.472 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: "Neutral Organic SAR (Baseline Toxicity)"; Substance is a neutral organic chemical, baseline toxicity value provided to be able to quantify the amount of excess toxicity to Daphnids.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
