Triethyl orthoacetate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-06-13 to 2017-06-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

140.3 °C

Atm. press.:

1 013.25 hPa

Decomposition:

no

Pre-Test

Formation of the bubble was observed at 128 °C. At 148 °C the bubble chain was visible and the burner was turned off. The chain broke at 139.9 °C. After cooling down no visual changes were observed.

Method following Siwoloboff (Main Test)

The measured values and all observations are presented in the following table.

Table 1: Measured values

Determination	Boiling Point	Atmospheric Pressure
First determination	139.1 °C (412.3 K)	98844 Pa
Second determination	139.6 °C (412.8 K)	98252 Pa

Table 2: Observations

Observations	First determination	Second determination
Individual bubble visible	133 °C	135 °C
Bubble chain; turned off heating plate	144.6 °C	144.5 °C
After cooling down	No visual changes were observed	No visual changes were observed

Evaluation

The boiling temperature at standard pressure can be calculated following the equation of Sidney-Young (only for small pressure deviations):

T_n= T+(f_T*Δp)

with

T_{n =}boiling point at 101.325 kPa in K

T = measured boiling point in K

f_T= rate of change of boiling temperature with pressure in K/kPa (temperature-related correction factor)

Δp = (101.325 - p) in kPa

p = measured atmospheric pressure in kPa

The temperature-related correction factor (f_T) was calculated as 0.34 K/kPa for all boiling point values (412.3 K and 412.8 K) using the following equation:

f_T= 0.000843636*T (in K) - 0.008984727

The result is calculated as mean of the two values of the duplicate determination.

Table 3: Corrected values following Sidney-Young

	Boiling point	Pressure in Pa	Corrected boiling point
First determination	139.1 °C (412.3 K)	98844 Pa	139.94 °C (413.09 K)
Second determination	139.6 °C (412.8 K)	98252 Pa	140.64 °C (413.79 K)
Mean			140.3 °C (413.4 K)

Mean ± standard deviation (after correction following Sydney-Young) = 140.3 ± 0.5 °C (413.4 ± 0.5 K) at standard pressure (101.325 kPa).

Conclusions:

The boiling point of the test item was determined to be 140.3 ± 0.5 °C (413.4 ± 0.5 K) at 1013.25 hPa.

Executive summary:

The study was performed according to OECD test guideline 103 and Regulation (EC) No. 440/2008 method A.2 in order to determine the boiling point of the test item by using the Siwoloboff method. During the determination no visual changes of the test item were observed. The mean boiling point of the test item was determined to be 140.3 ± 0.5 °C (corresponding to 413.4 ± 0.5 K). The value was calculated from two independent determinations, corrected to the standard pressure of 1013.25 hPa by using the Sidney-Young equation.

Description of key information

The boiling point of the test item was determined to be 140.3 ± 0.5 °C (413.4 ± 0.5 K) at 1013.25 hPa.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

140.3 °C

Additional information

The study was performed according toOECD test guideline 103 and Regulation (EC) No. 440/2008 method A.2 in order to determine the boiling point of the test item by using the Siwoloboff method. During the determination no visual changes of the test item were observed. The mean boiling point of the test item was determined to be 140.3 ± 0.5 °C (corresponding to 413.4 ± 0.5 K). The value was calculatedfrom two independent determinations, corrected to the standard pressure of 1013.25 hPa by using the Sidney-Young equation (reference 4.3-1).