Registration Dossier
Registration Dossier
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EC number: 201-781-2 | CAS number: 87-89-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Consensus model in Test v4.2.1
Model prediction report is attached in IUCLID - GLP compliance:
- no
- Test type:
- other: QSAR predicition
Test material
- Reference substance name:
- Myo-inositol
- EC Number:
- 201-781-2
- EC Name:
- Myo-inositol
- Cas Number:
- 87-89-8
- Molecular formula:
- C6H12O6
- IUPAC Name:
- cyclohexane-1,2,3,4,5,6-hexol
- Details on test material:
- - Purity: Not applicable
- Smiles: OC1C{P-}(O)C{P-}(O)C{P-}(O)C{P+}(O)C{P-}1O
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 19 483.68 mg/kg bw
- Remarks on result:
- other: QSAR predicted value
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 (rat): 19483.68 mg/kg
- Executive summary:
The consensus model in Times v4.2 was used to predict the acute toxicity to rats. The oral LD50 in rats was predicted to be 19483.68 mg/kg. Additional supporting documentation is provided in the prediction report attached in IUCLID.
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