Registration Dossier
Registration Dossier
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EC number: 203-319-5 | CAS number: 105-65-7
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Diisopropyl Xanthogen Disulphide
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- >= 97.8 - <= 100 % (w/w)
- Reference substance:
- Diisopropyl Xanthogen Disulphide
- Reference substance:
- Diisopropyl Xanthogen Disulphide
- This impurity is considered relevant for the classification and labelling of the substance
- PBT status:
- the substance is not PBT / vPvB
- Justification:
DIXD is a known to be a hydrolytic breakdown product from AS100 (the tetrasulfide, longer chain xanthogen) in water in pH above 7 (basic conditions). Review of aquatic toxicity results from AS100 is a valid method of read-across and AS100, pre-2000, had significant quantities of DIXD within its composition (up to 8%w/w). Results from the AS100 studies showed that it does degrade to DIXD and there is a question as to whether DIXD is persistent. A recent Chinese Fish Toxicity study has been used as the main study to denote low/non toxic behaviour for DIXD. This removes the possibility of DIXD being a PBT.
A recent assessment of AS100/DIXD by BIBRA has highlighted relevant studies demonstrating a common metabolic pathway for diallyl duslphides to be oxidised to thiosulphinate, by Cytochrome P450 enzymes and into allyl mercaptans. This is further metabolised by conujugation with glutathione (Teyssier and Siess, 2000) and subsequent metabolism resulting in a common product - methylethyl thioformate. This is strong evidence that there would be no bioaccumulation of DIXD which is also corroborated with the BCF predicted value of 33.6 - from OECD Canadian Domestic Substance List - https://canadachemicals.oecd.org/ChemicalDetails.aspx?ChemicalID=EB41B8A8-0D5C-46A2-A5DE-12F6C121BB02. This also negates the possible designation of DIXD as being a vPvB.
- Likely routes of exposure:
Human exposure:
Oral - not by dermal or inhalation
Environmental exposure:
Water
Pattern of exposure:
Accidental
Reference
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