Registration Dossier
Registration Dossier
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EC number: 206-573-5 | CAS number: 355-02-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- Test animals held in chamber containing the test substance.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Perfluoro(methylcyclohexane)
- EC Number:
- 206-573-5
- EC Name:
- Perfluoro(methylcyclohexane)
- Cas Number:
- 355-02-2
- Molecular formula:
- C7F14
- IUPAC Name:
- perfluoro(methylcyclohexane)
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: Atomised test fluid
- Duration of exposure:
- 6 h
- Concentrations:
- 2 % concentration of test material in sample (20,000 ppm)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 292 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- None
- Clinical signs:
- other: During the first hour 3 rats shown signs of laboured breathing. These signs disappeared after an hour.
- Body weight:
- The rate of growth of the test animals was similar to that of the control group.
- Gross pathology:
- Microscopic pathology revealled areas of consolidation in the lung of 2 rats.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
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