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EC number: 947-574-7 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Calculation of the combined chronic toxicity values of individual alkyl lactates (chVs) based on ECOSAR predicted ChVs for Ceraphyl 31.
- Principles of method if other than guideline:
- Calculation based on ECOSAR v1.1 Class-specific Estimations
- Analytical monitoring:
- not required
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- other: QSAR calculations
- Key result
- Dose descriptor:
- other: ChV = 10^([log (LOEC x NOEC)]/2)
- Effect conc.:
- 0.093 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- not specified
- Remarks on result:
- other: Ester based
- Details on results:
- ECOSAR v1.1 Class-specific Estimations:
Chronic values for alkyl lactates in Ceraphyl 31
C12 C14 C16
Invertebrates 0.427 0.086 0.017
C12 C14 C16
C12 composition 0.6 0.3 0.1
combined ChV - Invertebrates 0.093 mg/L
Reference
Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for invertebrates:
Calculated based on QSAR values for Ester Toxicity:
| Lactate | ChV | 1/ChV | f | f/ChV |
| Dodecyl lactate | 0.427 | 2.342 | 0.60 | 1.405 |
| Tetradecyllactate | 0.086 | 11.63 | 0.30 | 3.488 |
| Hexadecyllactate | 0.017 | 58.82 | 0.10 | 5.882 |
| Σf/ChV | 10.78 | |||
ChV ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters |
0.093 |
|||
f= estimated average fraction of chemical in mixtures
Description of key information
Chronic value (ChV) calculated based on QSAR estimated individual ChV values for the C12, C14 and C16 lactates being the main constituents of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.093 mg/L
Additional information
Estimation of the chronic value of Propanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters for invertebrates:
Calculated based on QSAR values for Ester Toxicity:
| Lactate | ChV | 1/ChV | f | f/ChV |
| Dodecyl lactate | 0.427 | 2.342 | 0.60 | 1.405 |
| Tetradecyllactate | 0.086 | 11.63 | 0.30 | 3.488 |
| Hexadecyllactate | 0.017 | 58.82 | 0.10 | 5.882 |
| Σf/ChV | 10.78 | |||
ChV ofPropanoic acid, 2-hydroxy, C12-C16 (even numbered) alkyl esters |
0.093 |
|||
f= estimated average fraction of chemical in mixtures
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