2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl}ethyl hydrogen phosphate

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 Jun - 28 Jul 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

adopted in 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

adopted in 2008

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

Storage conditions: Ambient temperature (10 to 30 °C)

Atm. press.:

1 013 hPa

Decomposition:

yes

Decomp. temp.:

ca. 165 °C

Results
DSC Measurement
DSC measurements in aluminium crucibles with a hole showed a multistage endothermal effect starting at 165 °C (see Table 1 ).

Table 1 – Melting point – DSC measurement

Test item [mg]	Starting temperature [°C]	Final test temperature [°C]	Temperature range (melting [°C]	Onset [°C]	Observations after first measurement
11.54	25	500	165 – 210	193.35	Test item was decomposed to black; mass loss 44%
6.87		200	165 - >200	Not evaluable	Test item decomposed to orange; no mass loss
6.20		220	170 – 215	194.18	Test item decomposed to orange; mass loss 4%

 

To clarify the meting range, an additional measurement with the capillary method was done.

Table 2 - Capillary Tube in a Metal Block Results

Set point [°C]	End point [°C]	Remarks
90	250	Approx. 204 °C: test item started to melt Approx. 211 °C: test item discoloured to reddish-brown and it appeared melted Approx. 238 °C: test item started to bubble (no further observations possible)

Conclusion: The test item melted under decomposition starting at 165 °C.

 

Description of key information

The test item melts under decomposition starting at 165 °C (OECD 102, DSC).