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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
Author:
Filov VA
Year:
1968
Bibliographic source:
Gig. Tr. Prof. Zabol. 7, 29-33

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
2 rats were exposed to vapor (concentration not mentioned); then amine concentration in blood was determined.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dicyclohexylamine
EC Number:
202-980-7
EC Name:
Dicyclohexylamine
Cas Number:
101-83-7
Molecular formula:
C12H23N
IUPAC Name:
N-cyclohexylcyclohexanamine
Test material form:
not specified
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
2 animals were exposed for 80 minutes via inhalation, with no data on doses

Administration / exposure

Route of administration:
inhalation
Vehicle:
other: air
Duration and frequency of treatment / exposure:
80min.
Doses / concentrations
Remarks:
Doses / Concentrations:
No data
No. of animals per sex per dose / concentration:
2
Control animals:
not specified
Details on study design:
no details
Details on dosing and sampling:
no details
Statistics:
no details

Results and discussion

Main ADME results
Type:
absorption

Toxicokinetic / pharmacokinetic studies

Details on absorption:
0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Details on distribution in tissues:
0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Details on excretion:
no data

Metabolite characterisation studies

Metabolites identified:
not specified
Details on metabolites:
no data

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:
no data

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: penetrated the alveolar membrane and entered blood stream
Executive summary:

Following inhalation exposure to DCHA, it was determined in blood indicating that dicyclohexylamine penetrates the alveolar membrane and enters the blood.