Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-465-5 | CAS number: 2157-01-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data from secondary source (peer-reviewed handbook). The data are reported to be unpublished, original data of the author (Fasset) from the Laboratory of Industrial Medicine, Eastman Kodak Co., Rochester NY Insufficient information to determine reliability
- Justification for type of information:
- Read across from the 2 Ethylhexyl methacrylate category member donor substance.
REPORTING FORMAT FOR THE CATEGORY APPROACH
see attached category document
PM_Lower Alkyl (C1-C8) Methacrylates
This is a category (C1-C8 Lower Alkyl Methacrylates) with clear trends in the physicochemical properties of its members, related to molecular weight, molecular size and hydrophilicity.
There are only limited acute dermal toxicity data for the members of the category C1-C8 Lower Alkyl Methacrylates available. Guideline studies are only available for MMA and nBMA. There are reliable data for MMA and nBMA indicating that these esters are of low acute dermal toxicity. There are also two early pre-guideline studies of limited reliability available in guinea pigs for i-BMA and 2-EHMA that indicate low acute dermal toxicity and although there is no fully valid study for 2-EHMA, the upper bound of the category, there is a trend of decreasing skin absorption across the category (see section 5.1) indicating that the acute dermal toxicity of all members will be equally low. This is supported by the observation that the members are all of low acute oral toxicity.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not known
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Octyl methacrylate
- EC Number:
- 218-465-5
- EC Name:
- Octyl methacrylate
- Cas Number:
- 2157-01-9
- Molecular formula:
- C12H22O2
- IUPAC Name:
- octyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Remarks on result:
- other: 17620 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- A published LD50 >20 ml/kg bw in guinea pigs is available.
- Executive summary:
A published LD50 >20 ml/kg bw in guinea pigs is available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
