Registration Dossier
Registration Dossier
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EC number: 947-403-6 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of test chemical in rat
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of test chemical was performed in rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride
- EC Number:
- 222-887-5
- EC Name:
- 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride
- Cas Number:
- 3648-36-0
- Molecular formula:
- C22H26ClN2.Cl
- IUPAC Name:
- 2-(2-{4-[(2-chloroethyl)(methyl)amino]phenyl}vinyl)-1,3,3-trimethyl-3H-indolium chloride
- Details on test material:
- - Name of test material (IUPAC name): 2-(2-{4-[(2-chloroethyl)(methyl)amino]phenyl}vinyl)-1,3,3-trimethyl-3H-indolium chloride- Common name: Astrazone pink FG- Molecular formula: C22H26ClN2.Cl- Molecular weight: 389.367 g/mol- Smiles notation: c12c([N+](C)=C(C1(C)C)\C=C\c1ccc(N(CCCl)C)cc1)cccc2.[ClH-]- InChl: 1S/C22H26ClN2.ClH/c1-22(2)19-7-5-6-8-20(19)25(4)21(22)14-11-17-9-12-18(13-10-17)24(3)16-15-23;/h5-14H,15-16H2,1-4H3;1H/q+1;/p-1- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2-(2-{4-[(2-chloroethyl)(methyl)amino]phenyl}vinyl)-1,3,3-trimethyl-3H-indolium chloride- Common name: Astrazone pink FG- Molecular formula: C22H26ClN2.Cl- Molecular weight: 389.367 g/mol- Smiles notation: c12c([N+](C)=C(C1(C)C)\C=C\c1ccc(N(CCCl)C)cc1)cccc2.[ClH-]- InChl: 1S/C22H26ClN2.ClH/c1-22(2)19-7-5-6-8-20(19)25(4)21(22)14-11-17-9-12-18(13-10-17)24(3)16-15-23;/h5-14H,15-16H2,1-4H3;1H/q+1;/p-1- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 2260 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- Details on study design :- Other examinations performed: clinical signs
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 260 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at dose 2260 mg/kg bw
- Clinical signs:
- In Clinical signs observation,changes in blood, change in blood or tissue levels( Transaminases) and Enzyme inhibition, induction were observed.
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 2260 mg/kg bw,when rats were treated with test chemical orally.
- Executive summary:
Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 2260 mg/kg bw.In Clinical signs observation,changes in blood,change in blood or tissue levels( Transaminases) and Enzyme inhibition, induction were observed.Hence,LD50 value was considered to be 2260 mg/kg bw,when rats were treated with test chemicalorally.
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