Registration Dossier
Registration Dossier
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EC number: 231-594-1 | CAS number: 7646-93-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Read-across conclusions for the following properties under consideration
The basis for the read-across concept for this project is the equilibrium between sulfates, hydrogensulfates, and sulfuric acid in aqueous solutions depending on pH value which is clearly described in published literature and summarised in the following equations:
H2SO4<-> HSO4-+ H+ HSO4-<-> H++ SO42-
As the nature of the cation should make no significant difference in this case concerning toxicity and solubility (all compounds are very soluble in water), only the chemical and biological properties of the anion are considered relevant. Based on the described equilibrium correlations, we propose unrestricted read-across between the groups of sulfates, hydrogensulfates and sulfuric acid concerning systemic toxicity.
The proposed read-across concept only applies to toxicological and ecotoxicological/environmental fate endpoints.
No data specifically for potassium hydrogensulfate on genotoxicity are available, thus read-across from data on sodium sulfate was performed.
Potassium hydrogensulfate dissociates in water to yield potassium cations, as well as hydrogensulfate and sulfate ions in a pH-dependent equilibrium. For this reason, it is considered fully justified to also read across from existun data for sodium sulfate:
For sodium sulfate, an Ames test, a mouse lymphoma study and a chromosome aberration test is available. The Ames test did not show mutagenic effects (Bayer 1988).
Based on the above test result, it is concluded that sodium sulfate has no genotoxic toxic potential. Hence, applying the described read-across concept, potassium hydrogensulfate does not require classification for genetic toxicity.
Justification for classification or non-classification
Based on read-across from data on sodium sulfate (negative results in AMES), it is concluded that potassium hydrogensulfate also lacks any genotoxic potential, and the substance therefore does not require classification for genotoxicity according to EC Regulation No. 1272/2008 and subsequent regulations.
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