2-hydroxyethyl [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] carbonate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993-12-06 to 1994-04-20

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point/Boiling Range)

Version / remarks:

1981

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

1992

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

signed 1994-03-16

Type of method:

other: method according to Siwoloboff and distillation method

Atm. press.:

99.67 kPa

Decomposition:

yes

Decomp. temp.:

225 °C

Boiling pt.:

>= 118 - <= 122 °C

Atm. press.:

0.133 kPa

Decomposition:

no

Remarks on result:

other: St. dev.: ± 1 °C

SIWOLOBOFF METHOD

Temperature [K]	Observations
297	The test material was a white powder
299 - 317	There was no change in the test material
328	The test material appearedmoistand began to shrink
331	The test material began tocollapse
337	The test material was mostly liquid
339	The test material had melted to a translucent, colourless liquid
339	The Siwoloboff tube was inserted
353 - 471	There was no change in the test material
498	The test material was bubbling. Brown solid was settling out of the test material
499	A bubble was emerging from the Siwoloboff tube
501	The first bubble was emitted from the Siwoloboff tube
503	The Siwoloboff tube began to emit bubbles at a steady rate
507- 510	The rate of production of bubbles had increased
512	The rate of production of bubbles had increased. The test material was slightly yellow. Brown solid was at the bottom of the Siwoloboff tube. The hegt was removed
457	The test material rose up the Siwoloboff tube

RESULT: Decomposed at 498 K prior to boiling.

Atmospheric pressure: 99.67 kPa.

 

DISTILLATION AT REDUCED PRESSURE

 

Sample temperature [K]	Vapour temperature [K]	Pressure [kPa]	Observations
292	293	0.133	The test material was a white solid.
299	294	0.133	The periphery of the test material began to melt.
324	294	0.133	The test material continued to melt.
381	295	0.133	The test material had fully melted and was beginning to vaporise.
391	295	0.133	The test material began to reflux.
399	296	0.133	Vapour moved further into the apparatus.
399	356	0.133	Vapour moved further into the apparatus.
399	383	0.133	There was no change in the test material.
399	388	0.133	There was no change in the test material.
400	391	0.133	The first drop of distillate entered the condenser.
401	391	0.133	Distillate was flowing through the condenser.
401	391	0.133	The first drop of distillate was collected.
401	391	0.133	Distillate was flowing into the collection vessel.
400	392	0.133	The distillate was a clear, colourless,viscous liquid.
*	392	0.133	There was no change in the test material.
*	393	0.133	There was no change in the test material.
*	393	0.133	There was no change in the test material.
*	393	0.133	The residue in the distillation flask appeared off-white.
*	393	0.133	There was no change in the test material.
*	395	0.133	The rate of production of distillate had slowed considerably. There was no change in the test material.
*	394	0.133	Production of distillate had virtually ceased.
*	394	0.133	There was no change in the test material.
*	393	0.133	There was no change in the test material. Approximately 99 % of the test material had distilled over. The residue was a tan coloured solid.

* The level of the molten test material was below the level of the thermometer pocket.

 

RESULT: Boiled between 391 and 395 ± 1 K at a reduced pressure of 0.133 kPa.

 

The test item decomposed at 498 K prior toboiling at atmospheric pressure.

The test item was found to boil between 391 and 395 ± 1 K at a reduced pressure of 0.133 kPa (approximately 99 % distillation).

Conclusions:

According to Council Directive 92/69/EEC A.2 and OECD Guideline 103 (1981), the test item decomposes at 225 °C prior to boiling at atmospheric pressure (99.67 kPa). The boiling range of the test item is 118 - 122 °C at reduced pressure of 0.133 kPa.

Description of key information

The test item decomposes at 225 °C prior to boiling at atmospheric pressure (99.67 kPa). The boiling range of the test item is 118 - 122 °C at reduced pressure of 0.133 kPa.