2-amino-2'-chloro-5-nitrobenzophenone

Endpoint summary

Description of key information

 Evaluation of Acute Oral (Gavage) Toxicity with ACN in Rats - 12/12/2005 _  KBL/2005/1516 Rpo

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08-12/2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

female

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

3 g test item filled up to 15 ml using a 0,5% (m/v) solution of Tylose MH 1000 in deionised water.
volume of aministation: 1 ml/100g ody weight

Doses:

2000 mg/kg b.w.

No. of animals per sex per dose:

6 female animals

Control animals:

no

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

>= 2 000 mg/kg bw

Mortality:

None of the animals died durng the course of investigation.

Clinical signs:

A slightly staggering gait in three animals and a slight apathy in one animal were observed on the day of administration.
A slight diarrhoea in one animal was obseved on the day after the administration.
All animals showed a slightly yellow discoloured urine up to the third day after the administration.

Body weight:

The body weight gain of the animals was not affected by the administration of the test item.

Gross pathology:

no pathological findings were observed.

Clinical observations, individual data

hours or day p.a	animal 1	animal 2	animal 3	animal 4	animal 5	animal 6
2h	A	0	0	0	0	0
3h	0	0	0	U	U	U
41/2h	0	U	0	-	-	-
6 h	AG	U	GU	U	U	U
71/2h	AGU	U	GU	-	-	-
1d	U	U*D	U	U	U	U
2d	U	U	0	U	U	U
3d	U	U	U	U	U	U
4d	0	0	0	0	0	0
5d	0	0	0	0	0	0
6d	0	0	0	0	0	0
7d	0	0	0	0	0	0
8d	0	0	0	0	0	0
9d	0	0	0	0	0	0
10d	0	0	0	0	0	0
11d	0	0	0	0	0	0
12d	0	0	0	0	0	0
13d	0	0	0	0	0	0
14d	0	0	0	0	0	0

legend:

0 = no signal observed

A = slight apathy

G = slightly saggering gait

U = slightly yellow discoloured urine

U* = red orange discoloured urine

D = slight diarrhoea

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The product is neither a toxic nor a harmful substance according to this acute oral toxicity study.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 000 mg/kg bw