Sodium glyoxylate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental starting date: 28 March 2017. Experimental completion date: 22 June 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Sodium glyoxylate

EC Number:

220-298-8

EC Name:

Sodium glyoxylate

Cas Number:

2706-75-4

Molecular formula:

C2H2O3.Na

IUPAC Name:

sodium oxoacetate

Specific details on test material used for the study:

Identification: Safelink SPM-01
Appearance/Physical state: colorless to slightly yellow powder
Batch: G150201
Purity: 99.9%
Expiry date: not supplied
Storage conditions: room temperature, in the dark

Results and discussion

Water solubility

Key result

Water solubility:

>= 16 - <= 18 other: % w/w

Conc. based on:

test mat.

Temp.:

20 °C

pH:

6.5

Any other information on results incl. tables

Preliminary Test

The sample concentrations, observations and solution pH are shown in the following table:

Sample	Concentration (% w/w)	Observation	Solution pH
1	5.16	Clear, colorless solution with no visible excess test item	6.7
2	10.3	Clear, colorless solution with no visible excess test item	6.5
3	20.4	Clear, colorless solution with visible excess test item	6.8
4	30.2	Clear, colorless solution with visible excess test item (more than Sample 3)	7.2
5	40.1	Clear, colorless solution with visible excess test item(more than Sample 4)	7.1
6	49.8	Clear, colorless solution with visible excess test item(more than Sample 5)	7.2

Preliminary water solubility: In the range 10 to 20% w/w at 20.0 ± 0.5 °C.

Definitive Test

The sample concentrations, observations and solution pH are shown in the following table:

Sample	Concentration (% w/w)	Observation	Solution pH
7	12.2	Clear, colorless solution with no visible excess test item	6.5
8	14	Clear, colorless solution with no visible excess test item	6.6
9	16	Clear, colorless solution with no visible excess test item	6.5
10	18	Clear, colorless solution with some visible excess test item	6.5

Water solubility: In the range 16 to 18% w/w at 20.0 ± 0.5 °C.

Applicant's summary and conclusion

Conclusions:

The water solubility of the test item has been determined to be in the range 16 to 18% w/w at
20.0 ± 0.5 °C.

Executive summary:

In the range 16 to 18% w/w at 20.0 ± 0.5 °C using a modified flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.