Registration Dossier
Registration Dossier
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EC number: 203-367-7 | CAS number: 106-15-0
Endpoint summary
Administrative data
Description of key information
Hydrolysis
HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 38000 yrs at pH 7.0 and at a temperature of 25ᵒC.
Additional information
Hydrolysis
Predicted data of the test chemical and various supporting studies for its structurally similar read across substance were reviewed for the hydrolysis end point which are summarized as below:
In a prediction done using the HYDROWIN v2.00 program of Estimation Programs Interface (2018), the hydrolysis half-life of test chemical was estimated. The estimated half-life of test chemical was determined to be 38000 yrs at pH 7.0 and at a temperature of 25ᵒC.
In a supporting study from authoritative database (2017), the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.030L/mol-sec with a corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively.
For the test chemical, the base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical (HSDB and PubChem, 2017). The second order hydrolysis rate constant of test chemical was determined to be 0.03L/mol-sec with a corresponding half-lives of 7.3 yrs and 266 days at pH 7 and 8, respectively.
On the basis of above results for test chemical, it can be concluded that the half-life value of test chemical was evaluated to be ranges from 266 days to 38000 yrs, respectively.
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