Registration Dossier
Registration Dossier
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EC number: 209-667-4 | CAS number: 589-98-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials: 3-Octanol
- Author:
- D. L. J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology,Volume 17, Supplement, December 1979, Page 881
- Reference Type:
- review article or handbook
- Title:
- Acute dermal toxicity study of 3-Octanol (589-98-0) in rabbit
- Author:
- John Wiley & Sons
- Year:
- 2 012
- Bibliographic source:
- Patty's Toxicology,Sixth edition,Volume 1,Pg.11,2012
- Reference Type:
- other: authoritative database
- Title:
- Acute dermal toxicity study of 3-Octanol (589-98-0) in rabbit
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- review article or handbook
- Title:
- Acute dermal toxicity study of 3-Octanol (589-98-0) in rabbit
- Author:
- Robert Tisserand and Rodney Young
- Year:
- 2 014
- Bibliographic source:
- Essential Oil Safety:A Guide for Health Care Professionals,Second Edition,2014
- Reference Type:
- publication
- Title:
- Microbial Volatile Organic Compounds
- Author:
- Anne Korpi, Jill Järnberg and Anna-Liisa Pasanen
- Year:
- 2 009
- Bibliographic source:
- Critical Reviews in Toxicology, Volume 39, 2009 - Issue 2, Pages 139-193
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity study of 3-Octanol (589-98-0) in rabbit
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
- Reference Type:
- secondary source
- Title:
- The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 138. Microbial volatile organic compounds (MVOCs)
- Author:
- Anne Korpi, Jill Järnberg and Anna-Liisa Pasanen
- Year:
- 2 007
- Bibliographic source:
- The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 138. Microbial volatile organic compounds (MVOCs), nr 2006:13,2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 3-Octanol (589-98-0) was performed in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Octan-3-ol
- EC Number:
- 209-667-4
- EC Name:
- Octan-3-ol
- Cas Number:
- 589-98-0
- Molecular formula:
- C8H18O
- IUPAC Name:
- octan-3-ol
- Details on test material:
- - Name of test material (IUPAC name): Octan-3-ol
- Common name: 3-Octanol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mol
- Smiles notation: C([C@@H](CC)O)CCCC
- InChl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):3-Octanol
- Molecular formula :C8H18O
- Molecular weight :130.229 g/mol
- Substance type:organic
- Physical state:Colorless Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at dose 5000 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with 3-Octanol (589-98-0) by dermal application.
- Executive summary:
In acute dermal toxicity study, rabbits were treated with 3-Octanol(589-98-0)in the concentration of 5000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 5000 mg/kg bw.Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with 3-Octanol (589-98-0)by dermal application.
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