Registration Dossier
Registration Dossier
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EC number: 200-040-0 | CAS number: 50-47-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Chemical Carcinogenesis Research Information System - desipramine
- Bibliographic source:
- Bethesda (MD): National Library of Medicine (US).
Materials and methods
Test material
- Reference substance name:
- Desipramine
- EC Number:
- 200-040-0
- EC Name:
- Desipramine
- Cas Number:
- 50-47-5
- Molecular formula:
- C18H22N2
- IUPAC Name:
- 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
- Test material form:
- not specified
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Test concentrations with justification for top dose:
- 1 - 5000 microg/plate
Results and discussion
Any other information on results incl. tables
Test System
AMES SALMONELLA TYPHIMURIUM
Strain Indicator
TA98; TA100; TA1535; TA1537
Metabolic Activation
NONE and with RAT, LIVER, S-9, AROCLOR 1254
Method
STANDARD PLATE
Dose
1-5000 UG/PLATE
Results
NEGATIVE
Applicant's summary and conclusion
- Conclusions:
- Desipramine has been resulted negative in one Ames test on TA98, 100, 1535, 1537 with and without metabolic activation.
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