Registration Dossier
Registration Dossier
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EC number: 201-474-3 | CAS number: 83-41-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: Literature (Handbook)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicological Evaluations: Potential Health Hazards of Existing Chemicals
- Author:
- Berufsgenossenschaft der chemischen Industrie
- Year:
- 1 995
- Bibliographic source:
- ISBN 3-540-59148-6; Springer-Verlag Berlin
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-nitro-o-xylene
- EC Number:
- 201-474-3
- EC Name:
- 3-nitro-o-xylene
- Cas Number:
- 83-41-0
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 1,2-dimethyl-3-nitrobenzene
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml/eye
Results and discussion
In vivo
- Irritant / corrosive response data:
- One hour after instillation, the conjunctiva showed diffuse crimson to severe red coloration accompanied by mild to marked conjunctival swelling.
The iris was reddened. The irritant effects were reversible from 48hours.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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