Registration Dossier
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EC number: 217-192-9 | CAS number: 1770-80-5
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- from peer-reviewed QSAR toolbox
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Oncorhynchus mykiss have been exposed during 96H to Dibutyl chlorendate in flow-though.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
- EC Number:
- 217-192-9
- EC Name:
- Dibutyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
- Cas Number:
- 1770-80-5
- Molecular formula:
- C17H20Cl6O4
- IUPAC Name:
- dibutyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
Constituent 1
Test solutions
- Details on test solutions:
- with Concurrent control
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Organism weight: 0.8 and 1.4g (two independent tests)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- Media hardness value = 272 mg CaCO3 /L water
- Test temperature:
- 16°C
- pH:
- 7.4
- Details on test conditions:
- dibutyl chlorendate is an insoluble substance
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.02 - <= 0.05 mg/L
- Nominal / measured:
- meas. (not specified)
- Basis for effect:
- mortality (fish)
- Details on results:
- Various results were obtained under various conditions, see screen capture attached. Only the two worst-case results are summarized here:
LC50 > 0.02mg/L in fish weighing 1.4g and LC50= 0.05 mg/L (range 0.038-0.066) in smaller fish weighing 0.8g.
The NOEC value was not indicated.
Applicant's summary and conclusion
- Conclusions:
- The test item, when tested in freshwater by flow-through during 96h, induced short term toxicity to Oncorhynchus mykiss: LC50 > 0.02mg/L in fish weighing 1.4g and LC50= 0.05 mg/L (range 0.038-0.066) in smaller fish weighing 0.8g.
The NOEC value was not indicated, but based on the mortality dose-response it may be assumed to range 0.01-0.038 mg/L.
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