Registration Dossier
Registration Dossier
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EC number: 282-031-1 | CAS number: 84082-84-8
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
Vetiveryl Acetate is a UVCB substance. For a complex and poorly soluble mixture, the acute effect loading level (typically expressed as the EL50) may be used directly for classification from aquatic toxicity tests performed using individually prepared water accomodated fractions (WAFs). Using this approach, an algal inhibition 72h EL50 based on growth rate was determined to be 76.6 mg/L. However, in an acute daphnia study using WAFs no clear biological dose response was observed with levels of immobility ranging from zero to <=30% indicating an EL50 of > 48.6mg/L. In a second acute daphnia study performed using dilutions of a saturated solution, a normal dose-response was observed and an EC50 of 7.2mg/L (based on measured dissolved organic carbon) obtained. Since all EL50/EC50 values are > 1mg/L the substance is not classified for short-term hazards to the aquatic environment according to the CLP Regulation 1272/2008/EC.
Chronic aquatic toxicity data is only available for one trophic level (algae). Therefore, the long-term hazard has been assessed based on both:
a) The chronic aquatic toxicity data for algae (EL10 = 22.1 mg/L) which results in no classification and
b) The acute aquatic toxicity data (daphnia EL50 > 48.6 mg/L, EC50 = 7.2mg/L ) and environmental fate data (not readily biodegradable and log Kow range of 2.6 to 7.1) which results in a chronic 2 classification
and classifying according to the most stringent outcome.
Thus it is concluded that the substance is classified Aquatic Chronic 2 (H411) according to the CLP Regulation 1272/2008/EC & adaptation 286/2011/EC.
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