Registration Dossier
Registration Dossier
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EC number: 223-746-0 | CAS number: 4046-24-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Germ cell mutagenicity data are not available for the substance. CE-4 is predicted by Mutagenicity (Ames test) model (KNN/Read-Across) 1.0.0 (VEGA QSAR) as NON-Mutagen.
Overall, available data are inconclusive for the classification of the substance according to Annex I of CLP Regulation.
Link to relevant study records
- Endpoint:
- genetic toxicity in vitro, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA. Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
- Version / remarks:
- May 2008.
- Deviations:
- not applicable
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
- Conclusions:
- Prediction is NON-Mutagen, the result appears reliable.
Reference
Prediction is NON-Mutagen, the result appears reliable.
The predicted compound is into the Applicability Domain of the model (AD index = 0.921).
Strongly similar compounds with known experimental value in the training set have been found (Similarity index = 0.849).
Accuracy of prediction for similar molecules found in the training set is good (Accuracy index = 1).
Similar molecules found in the training set have experimental values that agree with the predicted value (Concordance index = 1).
All atom centered fragment of the compound have been found in the compounds of the training set (ACF index = 1).
Additional information
Justification for classification or non-classification
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