Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7 odd-numbered alkyl) derivs. and sodium hydroxide and chloroacetic acid

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

To be completed

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

- Test item: REACH substance = freeze-dried commercial product
- Analytical purity: 97.2%
- Purity test date: 08 March 2017
- Lot:bacth No.: WI6G16X07 after drying
- Expiration date of the lot/batch: 16 July 2018
- Appearance: Off-white to yellow crystals
- Storage: At room temperature

Key result

Decomposition:

yes

Remarks on result:

not determinable

Preliminary test

Starting at 225°C, the weight of the sample decreased significantly. At 346°C, the sample weight had decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: off-white to yellow). The change of the colour indicated reaction and/or decomposition of the test item.

Main study

In Experiment 1, an endothermic peak was observed between 25°C and 100°C. The endothermic effect was due to evaporation of volatile components (the test item contains 2.8% water). An endothermic peak was observed between 100°C and 200°C. The extrapolated onset temperature of the peak was 137.708°C. The endothermic effect was most likely obtained due to melting and reaction and/or decomposition of the test item. From 200°C, an endothermic peak followed by an exothermic peak were observed. The effects were due to reaction and/or decomposition of the test item. After the experiment, a brown molten residue remained in the sample container.

Additional experiments (Experiment 2 to Experiment 4) were performed to investigate further the melting peak and confirmed that reaction and/or decomposition occurred during melting of the test item.

Conclusions:

The test item had no measurable boiling temperature since boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.

Executive summary:

The boiling point of the test item (= REACH substance) was investigated in a GLP-compliant study performed in accordance with EC A.2 method and OECD Guideline No. 103, using Differential Scanning Calorimetry (DSC). The test item had no measurable boiling temperature since boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.

Description of key information

The boiling point of the test item (= REACH substance) was investigated in a GLP-compliant study performed in accordance with EC A.2 method and OECD Guideline No. 103, using Differential Scanning Calorimetry (DSC). The test item had no measurable boiling temperature since boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.

Additional information

The boiling point of the test item was investigated in one GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.