Registration Dossier
Registration Dossier
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EC number: 206-033-9 | CAS number: 294-62-2
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Public information data 294-62-2
- Author:
- Chemicals Evaluation and Research Institute (CERI)
- Year:
- 2 002
- Bibliographic source:
- Web search 11 Feb. 2002
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyclododecane
- EC Number:
- 206-033-9
- EC Name:
- Cyclododecane
- Cas Number:
- 294-62-2
- Molecular formula:
- C12H24
- IUPAC Name:
- cyclododecane
- Details on test material:
- Test substance: Origin Tokyo Kasei Kogyo Co., Ltd; purity 100 %
Constituent 1
- Radiolabelling:
- no
Test solutions
- Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- - Vehicle: HCO-20, HCO-40
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISMS
- Size of fish: average weight 32.5 g, average total length 11.0 cm
- Lipid content of test organism: 5.4 % average
Study design
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- not specified
- Remarks:
- freshwater
- Total exposure / uptake duration:
- 70 d
Test conditions
- Test temperature:
- 25 +/- 1 degree C
- Details on test conditions:
- EXPOSURE CONDITIONS
- Exposure vessel: 100 l glass tank, 1155 l/day flow-through
- Concentration of test substance: 3 ug/l, 30 ug/l (nominal) - Reference substance (positive control):
- not specified
Results and discussion
Bioaccumulation factoropen allclose all
- Type:
- BCF
- Value:
- 3 860 - 17 900
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:30 µg/L
- Type:
- BCF
- Value:
- 3 690 - 18 100
- Basis:
- whole body w.w.
- Remarks on result:
- other: Conc.in environment / dose:3 µg/L
Depuration
- Elimination:
- no
Any other information on results incl. tables
- Measured vs nominal concentrations:
nominal: 1 2 4 6 8 10 weeks
30 ug/l: 11.3 11.6 12.3 13.8 14.9 15.2 ug/l
3 ug/l: 0.639 0.708 0.963 1.10 1.19 1.25 ug/l
- Bioconcentration factors
Range at 30 ug/l: BCF 3860-18700
Range at 3 ug/l: BCF 3690-18100
(2 determinations for each concentration and each time point listed above)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
