Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 272-818-8 | CAS number: 68915-97-9 A complex combination of hydrocarbons produced by the atmospheric distillation of crude oil. It boils in the range of approximately 282°C to 349°C (540°F to 660°F).
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
| Worker: Straight Run Gas Oils | |||||
| Effect | Route | DNEL | Dose Descriptor | Modified Dose Descriptor and Assessment Factors | |
| Acute Exposure | Systemic | Dermal | (a) | ||
| Inhalation | 1500 mg/m3/ 15 min (for lethality) [aerosol] | 1560 mg/m3/4 h (NOAEC based on lethality in acute inhalation study in rats) | Dose descriptor was modified to correct starting point of 16,723 mg/m3/15 min by adjustment for duration of exposure and level of activity. Then a total AF of 7.5 was applied for inter- and intraspecies differences. | ||
| Local | Dermal | (a) | |||
| Inhalation | (a) | ||||
| Long-Term Exposure | Systemic (b) | Dermal | 2.9 mg/kg/8h | 30 mg/kg/day | Dose descriptor was modified to correct starting point of 69.8 mg/kg/day by adjustment for dermal absorption.. Then a total AF of 24 was applied for subchronic to chronic and inter- and intraspecies differences. |
| (NOAEL basedon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats) | |||||
| Inhalation | 16 mg aerosol /m3/8h [aerosol] | 30 mg/kg/day | Dose descriptor was modified to correct starting point of 183.7 mg/m3/8 h by adjustment for dermal absorption, extrapolation from dermal to inhalation route, and ventilation in workers. Then a total AF of 7.5 was applied for inter- and intraspecies and remaining differences. | ||
| (NOEL basedon increased resorption, incomplete skeletal ossification, decreased foetal weights and decreased litter sizein a dermal developmental toxicity study in rats with dosing on GD 0-19) | |||||
| Local | Dermal | (a) for 13-wk exposures and | |||
| (c) for chronic exposures (dermal carcinogen) | |||||
| Inhalation | (a) | ||||
| a) No hazard identified for this route (data available) | |||||
| b) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown. | |||||
| c) No-threshold effect and/or no dose-response information available | |||||
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
| General Population Straight Run Gas Oils | |||||
| Effect | Route | DNEL | Dose Descriptor | Modified Dose Descriptor and Assessment Factors | |
| Acute Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Local | Dermal | (a) | |||
| Inhalation | (a) | ||||
| Long-Term Exposure | Systemic (b) | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Oral | 1.0 mg/kg/24h | 30 mg/kg/day | Dose descriptor was modified to correct starting point of 49.9 mg/kg/24 h by adjustments for dermal absorption, dermal to oral route, and duration and frequency of daily dosing. Then AF of 40 was applied for inter- and intraspecies differences and for total duration. | ||
| (NOAEL based onon increased liver and spleen weights, altered bone marrow function (decreased haematopoiesis, red blood cell count, haemoglobin, and haematocrit) and liver histopathologyin rats) | |||||
| Local | Dermal | (a) | |||
| Inhalation | (a) | ||||
| a) No DNEL needed since no exposure expected | |||||
| b) Long-term systemic effects include developmental/reproductive effects. Lowest DNEL is shown. | |||||
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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