Registration Dossier
Registration Dossier
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EC number: 812-243-7 | CAS number: 1189352-83-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- no
- Remarks:
- (study performed according to SOP in a laboratory that conforms to GLP but report not audited by the QAU)
Test material
- Reference substance name:
- 1-chloro-3-iodo-5-(trifluoromethyl)benzene
- EC Number:
- 812-243-7
- Cas Number:
- 1189352-83-7
- Molecular formula:
- C7 H3 Cl F3 I
- IUPAC Name:
- 1-chloro-3-iodo-5-(trifluoromethyl)benzene
Constituent 1
In vitro test system
- Test system:
- human skin model
- Remarks:
- Episkin
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: cutaneous irritation (Episkin)
- Remarks on result:
- positive indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- MR-008-2 (Q6F62), an intermediate product of ML925 synthesis, was irritant to the skin. It does require labelling with classification R38/H315 (category 2) and R41/H318 (category 1, i.e. irritant to the skin and therefore severely irritant to the eye) of the GHS.
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