Registration Dossier
Registration Dossier
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EC number: 250-961-7 | CAS number: 32220-82-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,1'-[(6-phenyl-1,3,5-triazine-2,4-diyl)diimino]bis[3-acetyl-4-aminoanthraquinone]
- EC Number:
- 250-961-7
- EC Name:
- 1,1'-[(6-phenyl-1,3,5-triazine-2,4-diyl)diimino]bis[3-acetyl-4-aminoanthraquinone]
- Cas Number:
- 32220-82-9
- Molecular formula:
- C41H27N7O6
- IUPAC Name:
- 1,1'-[(6-phenyl-1,3,5-triazine-2,4-diyl)diimino]bis[3-acetyl-4-aminoanthraquinone]
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6% to 35% suspension in 0.5% CMC
- Justification for choice of vehicle: test substance is not soluble in water or oranic solvents - Doses:
- 8000 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 d
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 8 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- Dyspnea, slight apathy; slight diarrhea, faeces stained blue
- Body weight:
- slight decrease in bw at study end
- Gross pathology:
- dilated heart, congestive hyperemia, dilated stomach with liquid content; intestines: diarrhetic content
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 (acute, oral) for rats was determined to be ca. 8000 mg/kg bw. test material (3200 mg/kg bw active ingredient)
- Executive summary:
The LD50 (acute, oral) for rats was determined to be ca. 8000 mg/kg bw.
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