Registration Dossier
Registration Dossier
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EC number: 212-112-9 | CAS number: 763-69-9
Endpoint summary
Administrative data
Description of key information
Non-GLP study equivalent to OECD guidelines 404 and 405 are available for ethyl 3-ethoxypropionate.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin: application of ethyl 3 -ethoxypropionate to rabbit skin resulted only in very slight effects in 1 out of 6 animals. All effects were fully reversible within 2 days.
Eye: in a study of acceptable quality (Klimisch 2) no eye irritation was observed any of the 6 animals (all scores were 0 after 24, 48 and 72 hours). In an older study (from 1946) with a Klimisch rating 4 (not assignable) 0.5 ml caused serious necrosis in the rabbit eye, while 0.1 ml caused only slight injury placing the compound in our grade 3 for eye injury. However, this study is not considered to be of acceptable quality as only insufficient details are provided in the study report and no data is available regarding impurities that might have influenced the irritation study.
Justification for classification or non-classification
Skin irritation: according to EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC) the mean value of the scores for erythema and for edema was 0.1. According to annex VI of the directive ethyl 3-ethoxypropionate is not classified as skin irritant.
Eye irritation: according to the annex VI of the council directive 67/548 EEC (amended by directive 83/467 EEC) the average scores for cornea, iris, conjunctivae and chemosis were 0 after 24, 48 and 72 hours for all animals. According to EEC criteria no labelling for eye irritancy is required.
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